Resident Population in St. Louis City, MO was 281.75400 Thous. of Persons in January of 2023, according to the United States Federal Reserve. Historically, Resident Population in St. Louis City, MO reached a record high of 622.23600 in January of 1970 and a record low of 281.75400 in January of 2023. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in St. Louis City, MO - last updated from the United States Federal Reserve on May of 2024.